Bertram A. Weber was born in Chicago, Illinois to Peter, an architect, and Bertha (nee Werkmeister) Weber. Weber enrolled at Northwestern University in 1916. With America's involvement in World War I growing, Weber put his studies on hold in 1918 to enter naval training. Soon after the armistice, he began work at his father’s architectural firm, remaining there eight months, after which he went back to school to pursue a bachelor's degree in architecture. He graduated from the Massachusetts Institute of Technology with this degree in 1922.
Fresh out of school, Weber worked a short time for Howard Van Doren Shaw. However, after his father’s death in 1923, Weber joined the family firm and along with Charles White formed White & Weber in 1924. Weber married Dorothea (nee Brammer) in 1928. They had two children, son John and daughter Dorie. After Charles White’s death in 1936 Weber began to practice independently, simply known as Bertram A. Weber, architect. In 1973 when his son joined him in his practice, Weber & Weber was formed.
Weber's career spanned almost 65 years, during which time he worked on a diversity of public, private residential, and commercial projects. Weber retired in 1987. He died two years later in 1989 in Pompano Beach, Florida.